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Zepbound, a brand name of tirzepatide, is FDA-approved for weight management when combined with increased physical activity and a reduced-calorie diet in adults with: Obesity (BMI 30 or higher) Overweight (BMI 27 or higher with at least one weight-related condition such as high cholesterol levels, hypertension (high blood pressure), type 2 diabetes, and cardiovascular disease Moderate to severe obstructive sleep apnea (OSA) Mounjaro contains tirzepatide as an active ingredient and is approved by the U.S
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It has been proved that normal hypothyroidism and subclinical hypothyroidism are independent risk factors for NASH and advanced fibrosis, which is one of the reasons why THR agonists are still being studied ( 3.1.6.1 Resmetirom (MGL-3196) In a 36-week randomized, double-blind, placebo-controlled, phase 2 study (NCT02912260), 125 patients with NASH and 10% hepatic steatosis confirmed by biopsy were randomly assigned to Resmetirom (80 mg) and placebo group
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